Cart
sales@molnova.com
Home - Products - Metabolic Enzyme/Protease - PAI-1 - XR 5118

XR 5118

CAS No. 174766-49-5

XR 5118( XR5118 )

Catalog No. M12648 CAS No. 174766-49-5

XR 5118 is a small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 3.5 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    XR 5118
  • Note
    Research use only, not for human use.
  • Brief Description
    XR 5118 is a small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 3.5 uM.
  • Description
    XR 5118 is a small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 3.5 uM, binds to PAI-1 and reduces plasma PAI-1 activity levels, promotes endogenous thrombolysis and inhibits thrombus accretion; the first nonpeptide compound with significant anti-PAI-1 activity in vivo.Thrombosis Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    XR5118
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    PAI-1
  • Recptor
    PAI-1
  • Research Area
    Cardiovascular Disease
  • Indication
    Thrombosis

Chemical Information

  • CAS Number
    174766-49-5
  • Formula Weight
    435.985
  • Molecular Formula
    C20H22ClN3O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    2,5-Piperazinedione, 3-[[5-[[2-(dimethylamino)ethyl]thio]-2-thienyl]methylene]-6-(phenylmethylene)-, monohydrochloride, (Z,Z)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Friederich PW, et al. Circulation. 1997 Aug 5;96(3):916-21. 2. Einholm AP, et al. Biochem J. 2003 Aug 1;373(Pt 3):723-32. 3. Folkes A, et al. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2589-92.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • AZ3976

    AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.

  • Aleplasinin

    Aleplasinin is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic system. Aleplasinin can be used in Alzheimer's disease studies.

  • UK-371804

    UK-371804 is a potent and selective inhibitor of urokinase-type plasminogen activator (uPA) with Ki of 10 nM.

Sign In Join Free